Indian Health Outcomes, Public Health and Economics Research Centre (IHOPE) Read More
Clinical Research
LVPEI has been successfully audited by United States - Food and Drug Administration Agency (US FDA) and European Medicine Agency (EMA) for performing clinical trials.
Dr Sayan Basu, Director of Research
Contact: 040-6810 2511
Mail: sayanbasu@lvpei.org
Kallam Anji Reddy Campus
Network Administrator: T. Charitha
Study Co-Ordinator’s: Vijaya, Ramya, Usha, Kavya, Sindupriya, Haripriya, Tejaswini
Study Optometrists: Swathi, Subba Rao
Contact Numbers (Clinical Research): 040-68102123/2124
Image reading centre:
Graders: Renuka Sai, Safia, Sushma
Contact Number: 040-6810 2170
Bhubaneswar Campus-Clinical Research
Clinical Research Coordinators: Asit, Mahima, S Das, Satyaprakash
Ethics Committee Coordinator: Jeweel Mohapatra
Study Optometrists: Kartik Jana
Contact Number: 06740 2653261
GMRV Campus-Clinical Research
Clinical Research Coordinator: Sumitra, Aishwarya
Contact Number: 9515263101 / 9182211204
KVC Campus-Clinical Research
Clinical Research Coordinator: Anusha
Contact Number: 7780309262
KAR CAMPUS- SPONSOR STUDIES |
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|---|---|---|---|---|---|
| S.No | Name of the project | Principal Investigator | Supported By | Duration | CTRI |
| 1 | Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes (FOCUS) | Dr.Padmaja Kumari | Novanordisk | 2020-2025 | http://ctri.nic.in |
| 2 | A Phase Iiib/iv, Multicenter, Open-label, Single-arm Study To Investigate The Efficacy And Safety Of Faricimab (ro6867461) In Patients With Polypoidal Choroidal Vasculopathy | Dr.Raja Narayanan | Roche Products PVT Ltd | 2024-2025 | http://ctri.nic.in |
| 3 | A phase III, multicenter, randomized, double masked, sham-controlled study to investigate the efficacy, safety, pharmacokinetics, and pharmacodynamics of RO7200220 administered intravitreally in patients with Uveitic Macular Edema | Dr. Mudit Tyagi | Roche Products PVT Ltd | 2024-2025 | http://ctri.nic.in |
| 4 | A Phase IIa, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared with Vehicle in Subjects with Fuchs Endothelial Corneal Dystrophy (FECD) – PHANTOM Study | Dr. Sunita Chaurasia | SANTEN | 2023-2025 | http://ctri.nic.in |
| 5 | A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with Amblyopia | Dr.Sampada Kulkarni | BYNOCS | 2024-2025 | http://ctri.nic.in |
| 6 | A phase 3 multicentre, double masked, Randomised, study to evaluate the efficacy and safety of intravitreal OPT-302 in combination with Aflibercept, compared with Aflibercept alone in patients with neovascular age related macular degeneration. | Dr.Vivek Dave | OPTHEA | 2023-2025 | http://ctri.nic.in |
| 7 | A Phase 1/2a Multi-Center, Dose-Escalation, Dose-Expansion Study to Evaluate the Safety and Efficacy of Eyecyte-RPETM when administered as a Single-dose Subretinal Injection in Subjects with Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (d-AMD) | Dr. Raja Narayanan | Eye Stem | 2024-2025 | http://ctri.nic.in |
INVESTIGATOR INITITATED STUDIES - KAR CAMPUS |
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|---|---|---|---|---|---|
| S.No | Name of the project | Principal Investigator | CTRI/Ethics Committee | ||
| 1 | Randomized Controlled Study on the Efficacy of Punctal Cautery in severe Dry Eye disease | Dr.Swati Singh | https://ctri.nic.in | ||
| 2 | Intraglandular platelet rich plasma injection in moderate to severe dry eye disease: A placebo-controlled trial | Dr.Swati Singh | https://ctri.nic.in | ||
| 3 | Artificial Intelligence enabled referral pathways for early diagnosis of complications arising from diabetes: application to diabetic retinopathy. | Dr.Padmaja Kumari Rani | https://ctri.nic.in | ||
| 4 | A Randomized, Placebo-controlled Study of the Efficacy, Safety & Tolerability of Intravitreal Brolucizumab in patients with Chronic Central Serous Chorioretinopathy with persistent fluid in the absence of choroidal neovascular membrane. | Dr Raja Narayanan | https://ctri.nic.in | ||
| 5 | Prospective comparative study of bleb morphology and surgical outcomes with and without use of Oral Doxycycline in patients undergoing trabeculectomy with mitomycin-C. | Dr Rashmi Krishnamurthy | https://ctri.nic.in | ||
| 6 | Safety And Efficacy of Collagenase application In Ocular Burns: A Prospective open- label Academic Randomized Controlled Trial. | Dr Sayan Basu | https://ctri.nic.in | ||
| 7 | A Proof-of-Concept study to Evaluate the Clinical Safety and Efficacy of Ex-vivo Cultivated Allogenic Limbal Stem Cell Transplantation for Treatment of Superficial Corneal Pathologies | Dr Sayan Basu | https://ctri.nic.in | ||
| 8 | A proof of concept study to evaluate the clinical safety and efficacy of Ex-vivo Cultivated Allogenic Limbal Stem Cell Transplantation for Treatment of Superficial Corneal Pathologies after Alginate encapsulation. | Dr.Sayan Basu | https://ctri.nic.in | ||
| 9 | Corneal Dystrophies Caused by SLC4A11 Mutation: A Promising New Paradigm Shift in Therapy Using an Ophthalmic Nonsteroidal Anti-Inflammatory Eye Drops | Dr.Muralidhar Ramappa | https://ctri.nic.in/ | ||
| 10 | The Endophthalmitis Management (EMS):The results of inflammatory score based management of post operative endophthalmitis | Dr. Vivek Pravin Dave | https://ctri.nic.in/ | ||
| 11 | Study of visual, optical, and structural parameters in eyes with nanophthalmos -SVOSPBN | Dr.Srihari Siddhartha | LEC-BHR-P-09-23-1103 | ||
| 12 | Safety and efficacy of 360-degree suture trabeculotomy in open angle glaucoma – A Multi-centric, prospective, non-randomized study | Dr.Rashmi Krishnamurthy | LEC-BHR-P -04-21-613 | ||
| 13 | The objective of this study is to compare the long-term safety and efficacy of PAUL ® Glaucoma Implant and Ahmed Implant in patients who are undergoing aqueous shunt implant surgery. | Dr. Sirisha Senthil | Ethics Ref: LEC-BHR-P-12-21-777 | ||
| 14 | To evaluate ocular surface changes secondary to anti-glaucoma medications | Dr. Gowri Pratinya | LEC-BHR-R-02-23-1005 | ||
MTC CAMPUS- SPONSOR STUDIES |
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|---|---|---|---|---|---|
| S.No | Name Of The Project | Principal Investigator | Supported By | Duration | CTRI |
| 1 | A phase 3 multicentre, double masked, Randomised, study to evaluate the efficacy and safety of intravitreal OPT-302 in combination with Aflibercept, compared with Aflibercept alone in patients with neovascular age related macular degeneration. | Dr. Tapas Ranjan | OPTHEA | 2023-2025 | http://ctri.nic.in |
| 2 | A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with Amblyopia. | Dr.Debasmita | BYNOCS | 2024-2025 | http://ctri.nic.in |
| 3 | A Multicenter, Double-Masked, Randomized, Vehicle-Controlled 12-Month (with a 12-month, Double-Masked Extension) Parallel Comparison of the Safety and Efficacy of 0.1% and 0.2% CBT-001 versus Vehicle, Dosed Twice-Daily, in Patients with Pterygium. | Dr. Sujata Das | Cloud break Therapeutics | 2024-2026 | http://ctri.nic.in |
| 4 | A Phase 2/3 Double-Masked, Randomized, 2-Stage, Multicenter Study of the Efficacy and Safety of OCS-01 Eye Drops in Subjects with Diabetic Macular Edema. | Dr. Umesh Chandra Behera | Oculis Operations | 2024-2025 | http://ctri.nic.in |
INVESTIGATOR INITITATED STUDIES - MTC CAMPUS |
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|---|---|---|---|---|---|
| S.No | Name of the project | Principal Investigator | CTRI/Ethics Committee | ||
| 1 | The Endophthalmitis Management (EMS):The results of inflammatory score based management of post operative endophthalmitis | Dr. Umesh Chandra Behra | https://ctri.nic.in | ||
| 2 | Identification of diagnostic biomarkers in vitreous/ aqueous fluid of ocular tuberculosis patients. | Dr Himansu Sekhar Behera | CTRI/2023/06/053753 | ||
| 3 | Safety and efficacy of autologous serum-based eye drops in the treatment of severe dry eye and ocular surface disorders. | Dr. Smruti Rekha Priyadarshini | 2023-161-BHR-52 | ||
| 4 | Diabetes and Diabetic Retinopathy Microbiome Study- India. | Dr Umesh Chandra Behera | 2023-175-BHR-3 | ||
| 5 | Longitudinal IOP and clinical outcomesin pseudoexfoliation stages and other primary glaucoma after medical treatment versus surgical treatment. | Dr Aparna Rao | 2022-130-BHR-46 | ||
GMRV CAMPUS - SPONSOR STUDIES |
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|---|---|---|---|---|---|
| S.No | Name of the Project | Principal Investigator | Supported By | Duration | CTRI |
| 1 | A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with Amblyopia | Dr.Virender Sachdeva | BYNOCS | 2024-2025 | http://ctri.nic.in |
INVESTIGATOR INITITATED STUDIES - GMRV CAMPUS |
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|---|---|---|---|---|---|
| S.No | Name of the project | Principal Investigator | CTRI/Ethics Committee | ||
| 1 | The Endophthalmitis Management (EMS):The results of inflammatory score based management of post operative endophthalmitis | Dr Rudvij Pandia | https://ctri.nic.in | ||
| 2 | Functional assessments of pathogenic variants in the nuclear and mitochondrial genome contributing to the pathogenesis of hereditary optic neuropathies | Dr Virender Sachdeva | LEC-BHR-07-22-131 | ||
| 3 | Objective Assessment of Pupillary Responses in Unilateral and Bilateral Optic Neuropathy using Pupil X | Dr.Virender Sachdeva | LEC-BHR-09-23-166 | ||
| 4 | Visual field examination with Virtual reality technology (Order of magnitude: OM Fields) in the Paediatric age group | Dr Virender Sachdeva | LEC-BHR-01-24-171 | ||
| 5 | Subclinical Gliptin-induced bullous pemphigoid in patients on oral gliptins | Dr Shilpa | LEC-BHR-02-24-172 | ||
INVESTIGATOR INITITATED STUDIES - KVC CAMPUS |
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|---|---|---|---|---|---|
| S.No | Name of the project | Principal Investigator | CTRI/Ethics Committee | ||
| 1 | The Endophthalmitis Management (EMS):The results of inflammatory score based management of post operative endophthalmitis | Dr Sameera Nayak | https://ctri.nic.in | ||
| 2 | Identification of diagnostic biomarkers in vitreous/ aqueous fluid of ocular tuberculosis patients | Dr.Sameera Nayak | CTRI/2023/06/053753 | ||